NanoCytes™

Nano mimic. Big impact. Nanoparticles that match the optical properties of real extracellular vesicles (EVs), available in fluorescent and unlabeled formats. Precision-engineered with the size and refractive index of extracellular vesicles. Pre-labeled fluorescent formats allow for clear, reliable signal detection and easy workflow integration for size estimation and instrument harmonization.

Refractive Index-Matched Sub-Micron Reference Controls

NanoCytes™ are synthetic reference particles, available in fluorescent and unlabeled formats, precision-engineered for sub-micron particle analysis. Each particle has a tuned refractive index designed to match the optical properties of biological extracellular vesicles (EVs), so they scatter light much like the biological samples being measured.

Every NanoCytes™ product is sold as a multi-size kit containing particles in three sizes, estimated at 100 nm, 200 nm, and 400 nm. This ladder covers the size range most relevant to EV research. Kits are available in several fluorescent colors matched to common laser lines and detection channels, as well as an unlabeled format for scatter-only analysis.

As stable, monodisperse refractive index-matched standards, NanoCytes™ provide a reproducible framework for estimating the sizes of biological EVs. The clear separation between sizes allows instrument performance to be qualified at high resolution and detection limits to be verified before running sub-micron samples. They are also suited to cross-site instrument benchmarking, supporting comparison of results across instruments, operators, and laboratories.

Ideal Use Cases

Use the ladder to estimate sizes of biological EVs, LNPs or large viruses
Determine instrument detection limit and qualify instrument performance
Cross-site instrument harmonization and benchmarking for comparison

Know your NanoCytes™

Every NanoCytes™ kit is a 3-size ladder estimated at 100 nm, 200 nm, and 400 nm. Choose the fluorescent color that matches your laser lines and detection channels, or go unlabeled for scatter only.